194 GLYCOSAMINOGLYCAN LOSS AND CHONDROCYTE DEATH
نویسندگان
چکیده
منابع مشابه
Joint aging and chondrocyte cell death.
Articular cartilage extracellular matrix and cell function change with age and are considered to be the most important factors in the development and progression of osteoarthritis. The multifaceted nature of joint disease indicates that the contribution of cell death can be an important factor at early and late stages of osteoarthritis. Therefore, the pharmacologic inhibition of cell death is l...
متن کاملType II collagen and glycosaminoglycan expression induction in primary human chondrocyte by TGF-β1
BACKGROUND A localized non-surgical delivery of allogeneic human chondrocytes (hChonJ) with irradiated genetically modified chondrocytes (hChonJb#7) expressing transforming growth factor-β1 (TGF-β1) showed efficacy in regenerating cartilage tissue in our pre-clinical studies and human Phase I and II clinical trials. These previous observations led us to investigate the molecular mechanisms of t...
متن کاملCartilage and chondrocyte pathology in the mucopolysaccharidoses: The role of glycosaminoglycan-mediated inflammation.
The mucopolysaccharidoses are a family of genetic diseases each caused by a defect in a lysosomal enzyme responsible for degradation of glycosaminoglycan (GAG) [11]. Failure of effective metabolism results in abnormal storage of GAG fragments, cell injury and death, and inflammatory responses. Because glycosaminoglycans are fundamental in connective tissue structure and function, the MPS disord...
متن کاملMapping Chondrocyte Viability, Matrix Glycosaminoglycan, and Water Content on the Surface of a Bovine Metatarsophalangeal Joint
OBJECTIVE The purpose of this study was to determine if there were variations in chondrocyte viability, matrix glycosaminoglycan (GAG), and water content between different areas of the articular surface of a bovine metatarsophalangeal joint, a common and reliable source of articular cartilage for experimental study, which may compromise the validity of using multiple samples from different site...
متن کاملGlycosaminoglycan profiles of repair tissue formed following autologous chondrocyte implantation differ from control cartilage
Currently, autologous chondrocyte implantation (ACI) is the most commonly used cell-based therapy for the treatment of isolated femoral condyle lesions of the knee. A small number of centres performing ACI have reported encouraging long-term clinical results, but there is currently a lack of quantitative and qualitative biochemical data regarding the nature of the repair tissue. Glycosaminoglyc...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2007
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(07)61827-5